This week's featured invention patented by Tennessee inventors is within CPC Section C: Chemistry & Metallurgy.
Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Inventor(s): P. Jeffrey Conn, Brentwood; Craig W. Lindsley, Brentwood; Corey R. Hopkins, Nolensville; Colleen M. Niswender, Brentwood; Rocco D. Gogliotti, Kingston Springs; James M. Salovich, Nashville; Darren W. Engers, Nashville; Yiu-Yin Cheung, Franklin
Assignee(s): Vanderbilt University, Nashville
Abstract: Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.